Coach Daisy Bag, (+)-MK-801 powder 77086-22-7. This Item27455349925M7571form. powderform. solidform. liquidform. powdercolor. whitecolor. ‑color. ‑color. white to beigeGene Information. ‑Gene Information. ‑Gene Information. ‑View 4 more rows Coach Dinky Bag, Scholarly articles for mk-801 sigma. ‎Bouchard - Cited by 59Phencyclidine and psychotomimetic sigma opiates: … - ‎Sonders - Cited by 198 Coach Flight Bag, Mk-801. (+)-MK-801 hydrogen maleate. Synonym(s): (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate, Dizocilpine hydrogen . Puma Speeder Mesh, (−)-MK-801 =98 HPLC 77086-19-2. MK-801 hydrogen maleate ≥98% (HPLC); CAS Number: 77086-19-2; Synonyms: (5R,10S)-(–)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen . Coach Leopard Bag, (+)-MK 801 Maleate. A highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, . 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Synonym(s): (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate, Dizocilpine hydrogen . Hockey Coach Bag, Behavioral evidence for modulation by sigma ligands of (+) .. by S Okuyama · 1996 · Cited by 22 — The selective non-competitive N-methyl-d-aspartate (NMDA) antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo(a, d)cyclohepten-5, 10-imine maleate ((+)MK-801) . Vintage Coach Ergo Hobo Bag, Mk 801. This product is suitable for DNA precipitation from low salt aqueous buffers. It has been tested for the absence of proteases and nucleases. The Ben Show Football Coach, 475878 Sigma-Aldrich(+)-MK 801 Maleate - CAS 77086-22-7. 475878 Sigma-Aldrich(+)-MK 801 Maleate - CAS 77086-22-7 - Calbiochem · A highly potent, selective, and non-competitive NMDA receptor antagonist that acts by .Brand Family: Calbiochem®Storage: +2°C to +8°C 2017 Thor Motor Coach, Sigma-Aldrich/(+)-MK-801 hydrogen maleate powder. Product#, M107-25MG-SI, CAS No. 77086-22-7, (M)SDS 규격서. M.F., M.W. 기술 데이터. 녹는점/어는점, -. 초기 끓는점 및 범위, -. 인화점, -. 비중, -. 4475 S Coach Drive, (+)-MK-801 hydrogen maleate powder, Sigma-Aldri.. [Sigma-Aldrich]. (+)-MK-801 hydrogen maleate powder. 239,990 원 ~. 장바구니에 상품이 담겼습니다. . Sigma-Aldrich(sigma). 브랜드 상품 더보기 .₩239,990 · ‎In stock All India Civil Service Coaching Centre, (+)-MK-801 HYDROGEN MALEATE > Sigma-Aldrich. MSDS 링크, https://www.sigmaaldrich.com/MSDS/MSDS/DisplayMSDSPage.do?country=DE&language=EN&productNumber=M107&brand=SIGMA. M107-50MG 제품설명, (+)-MK-801 . Puma Sport Shirt Damen, (+)-MK-801 hydrogen maleate, powder. For intracerebral hematomas, MK-801 might act as a potent supplement to reduce delayed edema after recombinant tissue plasminogen activator (rtPA) clot lysis.€1,402.39 Asl Coach, Millipore Sigma M107-25MG (+)-MK-801 Hydrogen .. Millipore Sigma M107-25MG (+)-MK-801 Hydrogen Maleate, 25mg: Amazon.com: Industrial & Scientific.$307.14 Breakthrough Coaching, (+)-MK 801 maleate ≥99% (HPLC) | Dizocilpine | 924. Apr 4, 2020 — (+)-MK 801 maleate is a high affinity (Ki = 37.2 nM), selective and non-competitive NMDA receptor antagonist. (+)-MK 801 maleate acts by . Rating: 5 · ‎1 review Business Coach Beachwood, Sigma Aldrich Fine Chemicals Biosciences MK-801 .. Shop Sigma Aldrich Fine Chemicals Biosciences MK-801 HYDROGEN MALEATE PO at Fishersci.com.$295.47 Career Coach Denver, Behavioral evidence for modulation by sigma ligands of (+) .. by S Okuyama · 1996 · Cited by 22 — (+)MK-801-induced hyperlocomotion in monoamine depleted mice is a unique animal behavior for studying functions of the brain in vivo , as related to the . Cheer Coaches, (M107) (+)-MK-801 hydrogen maleate - MilliporeSigma. Classification. Hydrocarbon ; Previous Suppliers. Sigma-Aldrich ; Molecular Weight. 337.4 ; Inchi Key. QLTXKCWMEZIHBJ-RCPFAERMSA-N ; IUPAC Name. but-2-enedioic acid . Chi Chi Brazil Coach, Effects of MK-801 (dizocilpine) on Brain Cell Membrane .. PDFby SY Ko · 2003 · Cited by 9 — Meningitis was induced by injection of 108 colony for- ming units (CFU) of E. coli in 100 Lof saline into the cister- na magna. In MK, 3 mg/kg of MK-801 (Sigma, . Chris Howard Football Coach, SIGMA/M107 - (+)-MK-801 hydrogen maleate. (+)-MK-801 hydrogen maleate. SIGMA/M107 - powder. Synonym: (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate; . Puma Stacker, Images for mk-801 sigma. by D Pubill Sánchez — EL MK-801 (dizocilpino), además de su conocido efecto como antagonista NMDA, es capaz de potenciar el efecto contráctil de la noradrenalina (NA), tanto exógena . Coach Camo, Cannabidiol Reverses MK-801-Induced Disruption of .. by LE Long · 2006 · Cited by 216 — MK-801 (0.3–1 mg/kg i.p.) dose dependently disrupted PPI while . Monash University), MK-801 (Sigma, Australia), Tween® 80 (Sigma, . Coach Casey Smith, Efecte de l'MK-801 i altres lligams PCP I Sigma sobre l'activitat .. by AM Canudas Teixidó · 1996 — Title: Efecte de l'MK-801 i altres lligams PCP I Sigma sobre l'activitat noradrenèrgic. Author: Canudas Teixidó, Anna-Maria. Director/Tutor: Escubedo Rafa, . Coach Credit Card, Interaction of sigma and PCP-like drugs on operant .. by TJ Hudzik · 1992 · Cited by 17 — The effects of the PCP-receptor selective drug MK-801 were compared to those of the mixed sigma/PCP drug (+)-NANM after each were combined with doses of . Coach Cruella Deville, MK-801 hydrogen maleate. (+)-MK-801 hydrogen maleate. Cat No: AOB1436. Condition. CAS No: 77086-22-7 (free base: 77086-21-6). Chemical Name:; Dizocilpine hydrogen maleate; .$15.00 Coach Dolphin Mall, depressant-like effect of MK-801(dizocilpine), a NMDA r. PDFby A Dhir · 2008 · Cited by 46 — antidepressant-like action of MK-801 (dizocilpine; N-methyl-d-aspartate receptor antagonist) in the mouse . were used: MK-801 (Sigma Chemicals, MO, USA),. Puma Sticker, (+)-MK-801 hydrogen maleate powder Sigma M107. This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of . Coach Japan, (+)-MK 801 maleate (CAS 77086-22-7). View and buy high purity (+)-MK 801 maleate. Non-competitive NMDA antagonist; acts at ion channel site. Cited in 91 publications. Coach Jessie Bowen, Sigma Ligands Indirectly Modulate the NMDA Receptor-Ion .. by H Yamamoto · 1995 · Cited by 112 — maleate (MK801) in- hibited 3H-TCP intact cell binding in a competitive manner, while haloperidol inhibited it in a noncompetitive manner. Coach K Collapse, FARMAKOLOGICKÝ PROFIL DIZOCILPINU (MK-801 . - MMSL. by J Konečný · 2019 — PHARMACOLOGICAL PROFILE OF DIZOCILPINE (MK-801) AND ITS POTENTIAL USE IN ANIMAL . impairments induced by MK-801 via a sigma receptor-related mechanism. Coach Mini Rowan, Reversible Changes in BDNF Expression in MK-801- .. by W Yu · 2021 · Cited by 6 — Astrocytes were detached using 0.25% EDTA-trypsin (Sigma, St. Louis, MO, United States) and passaged. Experiments were initiated after the . Puma Style Number Lookup, Dizocilpine (MK-801) induces distinct changes of N-methyl-d .. by D Xi · 2009 · Cited by 88 — We investigated the effects of the NMDAR antagonist dizocilpine (MK-801) on the . control and five groups of treatment with MK-801 (Sigma-Aldrich, USA), . Coach Of Arizona Cardinals, Differential binding properties of [H-3]dextrorphan and [ .. PDFJul 1, 2005 — NMDA receptor; Dextrorphan; MK-801; Glutamate; Binding; Mutagenesis . (DMEM) (Sigma, St. Louis, MO) supplemented with 10% fetal bovine . Coach Order Tracker, Sustained antidepressant action of the N‑methyl‑D .. by BK Yang · 2018 · Cited by 17 — Studies have indicated the rapid antidepressant effects of MK‑801 in animal . 0.9% saline), MK-801 (0.1 mg/kg, Sigma-Aldrich; Merck KGaA, . Coach Pitch, Inhibition of N-methyl-D-aspartate receptors by haloperidol. by DR Lynch · 1996 · Cited by 71 — Other agents acting at the sigma receptor inhibit binding of 125I-(+) MK 801 to NMDA receptors, and are slightly more potent at neonatal . Coach Rob Elac, The Delayed Effects of DTG and MK-801 on Latent .. PDFby SM TURGEON · 2000 · Cited by 33 — of the selective sigma receptor agonist 1,3-Di(2-tolyl)guanidine (DTG) and the selective NMDA receptor antagonist MK-801 on latent inhibition were assessed . Coach Swagger, The effect of NMDA-R antagonist, MK-801, on neuronal .. Oct 13, 2019 — We found that MK-801 had the opposite effect than expected, . NMDA-R antagonist (MK-801 hydrogen maleate, M107 Sigma-Aldrich). Coach Sweatpants, Effects of Dizocilpine (MK-801) via Up-modulation of N-methyl .. PDFby JH Kim · 2014 — ionchannel MK801 binding site has suggested that . Dizocilpine was purchased from Sigma (St. Louis,. MO, USA). Coach T Football, Biologically active MK-801 and SKF-10047 binding sites .. by R Maneckjee · 1992 · Cited by 17 — We have shown previously that cultured human lung cancer cells of different histologic types express multiple opioid receptors that can . Coach Umbrellas, Sigma Aldrich (+) -mk-801 Hydrogen Maleate (Dizoci| at Zoro. Description. SIGMA ALDRICH (+)-mk-801 hydrogen maleate (dizocilpine maleate) M107-25MG.£369.99 Coach Warehouse Jacksonville Fl, PRE-084, a sigma selective PCP derivative, attenuates MK .. PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice. ​. Anavex-1-1666x833.png. Coach Wizard Of Oz, The effect of the NMDA receptor antagonist MK-801 on .. by JM Langton · 2007 · Cited by 99 — Rats were injected with MK-801 prior to fear conditioning or extinction training. . MK-801 (Sigma-Aldrich) or saline was administered subcutaneously at a . Coaches Or Coach's, Nitric Oxide-Dependent Mechanisms Underlying MK-801- .. by P Cieślik · 2021 · Cited by 4 — MK-801, an NMDA receptor antagonist, and scopolamine, a cholinergic receptor blocker, . The membranes were blocked for 30 min with 5% BSA (Sigma-Aldrich, . Coaching Ontologico, Effects of ketamine, s-ketamine, and MK 801 on proliferation .. by M Malsy · 2015 · Cited by 54 — The NMDA antagonists ketamine, s-ketamine, and MK 801 inhibited cell . Adherent cells were rinsed with warm PBS (Sigma Aldrich) and . Dempsey Carryall Coach, Reactive Transformation and Increased BDNF Signaling by .. by W Yu · 2015 · Cited by 23 — MK-801, also known as dizocilpine, is a noncompetitive N-methyl-D-aspartic acid (NMDA) receptor antagonist that induces schizophrenia-like symptoms. Denver Broncos Head Coach Candidates, (+)-MK-801 hydrogen maleate, powder. CAS Number: 77086-22-7; Molecular Formula: C16H15N; Purity Grade: powder; Molecular Weight: 337.37; Shipped on ICE/no ICE: STD; SAP Pack with Pack Qty . Dialect Coach Heidi, Efecto del mk-801 y otros ligandos pcp y sigma sobre . - Dialnet. by DP Sánchez · 1997 — Información de la tesis doctoral Efecto del mk-801 y otros ligandos pcp y sigma sobre la neurotransmision noradrenergica periferica. Dune Coach, (+)-MK 801 maleate (0924). View and buy high purity (+)-MK 801 maleate from Tocris Bioscience, a Bio-Techne brand. Non-competitive NMDA antagonist; acts at ion channel site. Rating: 5 · ‎1 review Football Coach Costume, Effects of Cannabidiol on MK-801-Induced Locomotor .. PDFby SK Cronin · 2012 — noncompetitive( NMDA( receptor( antagonist( MK:801( maleate( was( used( to( induce( . ((MK:801(maleate((Sigma(Chemicals,(St.(Louis(MI)(was(. Intuitive Life Coach, The anticonvulsant MK-801 is a potent N-methyl-D .. by EH Wong · 1986 · Cited by 2205 — These comprised the dissociative anesthetics phencyclidine and ketamine and the sigma-type opioid N-allylnormetazocine (SKF 10,047). Neurophysiological studies . Ivy Coach Blog, Effects of memantine and MK-801 on ischemia in an .. by A Sencer · 2008 · Cited by 9 — . experimental acute subdural hematoma and the effect of memantine (Sigma M-9292) and MK-801 (Sigma M-107) in the treatment of ischemia. Puma Swede Teacher, Effects of Chronic Blockade of N-Methyl-D-Aspartate .. Oct 1, 2003 — However, chronic MK-801 treatment did not affect bladder weight in . NMDA receptor antagonist MK-801 (Sigma Chemical Co., St. Louis, . Mariconera Coach, (+)-Dizocilpine (MK 801) Maleate | 99.94%(HPLC) | In Stock. (+)-Dizocilpine (MK 801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes. Rating: 5 · ‎$79.00 Mini Coach Bus, Neonatal MK-801 treatment differentially alters the effect of .. Jul 17, 2013 — Male and female rats were postnatally exposed to MK-801 or saline and . 10-imine hydrogen maleate) was purchased from Sigma (St. Louis, . Multi-cultural Coaching: Coaching Minority Based Clients, Cell type-specific pharmacology of NMDA receptors using .. by Y Yang · 2015 · Cited by 18 — The small molecule NMDA-receptor antagonist MK801 has been . United States) was dissolved in dimethylsulfoxide (Sigma) (1–2 mg/ml) then . Naruto Coach, Age-dependent divergent interactions between CX3CR1 .. PDFby FA Méndez · 2023 — Fractalkine receptor (CX3CR1) depletion and MK-801 treatment had a . intraperitoneal (IP) dose of MK-801 (Sigma, Missouri, USA), or an. Ohio Coach, Biologically active MK-801 and SKF-10047 binding sites .. by R Maneckjee · 1992 · Cited by 17 — . (MK-801) and sigma N-allylnormetazocine (SKF-10,047) receptor ligands. . However, the mu and delta opioid ligands did not compete for (+) MK-801 and . Ontological Coaching, Comparison of the pharmacological properties of GK11 .. PDFby D Vandame · 2007 · Cited by 14 — and MK801, two NMDA receptor antagonists: towards . poly-D-Lysine (Sigma-Aldrich, Saint Louis, MO, USA) and laminin (Invitrogen, Cergy. Paulo Bento Teams Coached, Fenfluramine acts as a positive modulator of sigma-1 receptors. by P Martin · 2020 · Cited by 64 — . hydrogen maleate ((+)-MK-801, dizocilpine) were from Sigma-Aldrich (Saint-Quentin-Fallavier, France). 4-Methoxy-3-(2-phenylethoxy)-N . Quick Coach, Sigma-1 and N-Methyl-D-Aspartate Receptors. Mar 11, 2015 — Sigma-1 receptors (σ-1R) are interorganelle signaling molecules, . a sigma selective PCP derivative, attenuates MK-801-induced impairment . Rainbow Coaching, Protective Effect of Dizocilpine (MK-801) On TNBS-Induced .. by E Motaghi · 2019 · Cited by 1 — Dizocilpine, hexadecyl trimethyl-ammonium bromide (HTAB), O-dianisidine dihydrochloride, and TNBS were procured from Sigma-Aldrich (Saint Louis, Missouri, USA). Rice Football Coaches, Effects of the NMDA receptor antagonist MK-801 on female .. MK-801, as a high-affinity antagonist of NMDA receptors(Wong et al., 1986), . Sigma, Deisenhofen,Germany) with Hank's salts and sodium bicarbonate, . Stanways Coaches, Supplementary table 1. Specificity of NMDAR antagonists. PDFKi (vs [3H]MK-801) 1-2.5 μM. (1). ACh receptors . (+)-MK801 may be a strong I(Na) and I(to) blocker . phencyclidine, sigma and muscarinic receptors. Puma Tarmac Golf Joggers, Print version ISSN 0120-548X. by L BLANCO LEZCANO · 2011 — EFECTO DE LA ADMINISTRACIÓN INTRACEREBRAL DE MK-801 Y (-) NICOTINA EN LAS . Cada rata recibió 3 µL de una solución que contenía 8 µg de 6-OHDA (Sigma, . Teambeachbody Coach Login, Interaction of [3H]MK-801 with multiple states of the. by DC Javitt · 1989 · Cited by 100 — ligand [3H]MK-801 were determined in rat brain. Scatchard . affinities of both components of [3H]MK-801 binding as well as . from Sigma.Synergistic Effects of Citicoline and MK-801 in Temporary .. by MZ Önal · 1997 · Cited by 118 — MK-801 is a potent, noncompetitive NMDA receptor antagonist that blocks the . in a 2% solution of 2,3,5-TTC (Sigma) at 37°C and fixed by immersion in a .Bivalent Effects of MK-801 on Ethanol-Induced .. PDFby PJ Meyer · 2003 · Cited by 51 — MK-801's effects on ethanol sensitization appeared to be related to its own behavioral effects, rather than NMDA receptor . MK-801 (Sigma, St. Louis,.Incomplete block of NMDA receptors by intracellular MK-801. PDFby W Sun · 2018 · Cited by 10 — Intracellular MK-801 does not completely block synaptic NMDAR current. . Picrotoxin (50 μM, Sigma) and NBQX (5 μM, Tocris) were.PRE-084. PRE-084 is a sigma receptor agonist, selective for the σ1 subtype. . "PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of .Excitatory amino acids, NMDA and sigma receptors: A role .. by KLR Jansen · 1991 · Cited by 8 — Carlsson, M. & Carlsson, A. (1989a) The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine depleted mice.(+)-MK 801 maleate | Dizocilpine. Buy (+)-MK 801 maleate - a low cost, high quality NMDA receptor antagonist manufactured by Hello Bio, a trusted supplier for life science researchers. Rating: 100% · ‎8 reviews · ‎$45.00 · ‎In stockDextromethorphan. Dextromethorphan (DXM) is a cough suppressant in over-the-counter cold and cough medicines. It affects NMDA, glutamate-1, and sigma-1 receptors in the brain, . Uncompetitive antagonist of the NMDA receptor via the MK-801/ PCP site .K9 scent detection equipment. $184. 1 pair of stainless steel .. Sigma Pseudo corpse scent 2. In most mammals, including dogs, . Private Dog Training • K9 Equipment / Food (801) 698-2396. A detection dog (detector .(-)-MK 801 maleate - NMDA receptor antagonist. The effects of dizocilpine maleate (MK-801), an antagonist of the N-methyl-D-aspartate receptor, on neurologic recovery and histopathology following .$54.00 · ‎In stockFantaziye Bak Mk.! - YouTube. 0:23Fantaziye Bak Mk.!. 811K views · 2 weeks ago TÜRKIYE .more . Comments801. buraj Yssgys . Sigma Erkek Nasıl Kız Tavlar?YouTube · Lucifer Michaelson · 3 weeks agoRyan brewer plane. A phone number associated with this .. 24 records — . at Delta Airlines Phone Number US :1800-801-4127 Eight plays later Brewer took a . Skilled in operational/capital budgeting, lean/six sigma, .Sigma Software - Custom Software Development Company. Sigma Software development company offers turnkey solutions development and software development teams. Learn how our 2000 experts can support a project.Untitled. Md 801r tascam us 122. Audi hill hold assist q5. . Mortal kombat warehouse mk 37. Jam tangan casio ori murah kaskus co. . Pulsometr sigma rc 1209 forum?Tyton joint vs mechanical joint. All ductile iron Toggle Navig. 2000 South Provo, UT 84606 801-373-6910 POCKET ENGINEER Available for iOS + . correctly inserting the gasket into the gasket seat, The SIGMA ONE-LOK .Ti servono dei manuali? Scarica gratis e in fretta tutti I manuali!. Sigma manuali. Sigma · Jura manuali. Jura · Nikon manuali . Whirlpool SP40 801/ LH. manuale4 pagine · Lavazza Deséa . 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Bush-bashing, "blame America first"-crowd traitor. com or call 801-629-8037. Ames was critically injured, but recovered from his wounds.NIDA Research Monograph - Page 158 - Google Books Result. 1976 · ‎Drug abuseGutstein , H.B .; Trujillo , K.A .; and Akil , H. MK - 801 inhibits the . Larson , A.A. , and Sun , X. Regulation of sigma activity by the amino- terminus .lypm52 PDF资料大全 - Datasheet - 电子工程世界. . RNCF0805DKE54K9 D55342E07B57D6S B43HP-34CP-9 CC127LZ-A6BC-32.000AQ 240-801-07ZL6-4SSPEB . ADC基础知识分享- SAR 和 Delta Sigma ADC 基础知识 .The Role of Neurotransmitters in Brain Injury. W.D. Dietrich, ‎M.Y.T. Globus · 2012 · ‎ScienceGroup III: Three rats were pretreated with MK-801 (Research Biochemicals . Type II (Sigma Chemical Co., St. Louis, MO) dissolved in physiological saline.From Messengers to Molecules: Memories are Made of These. Gernot Riedel, ‎Bettina Platt · 2004 · ‎MedicalBehavioral evidence for a modulating role of sigma ligands in memory processes . I. Attenuation of dizocilpine ( MK - 801 ) -induced amnesia .(+)-MK 801|Potent NMDA antagonist. (+)-MK 801 is a potent antagonist of NMDA with Ki value of 30.5nM [1].MK 801 is a potent anticonvulsant exhibits both anxiolytic and sympathomimetic .CNS Neurotransmitters and Neuromodulators: Glutamate. Trevor W. Stone · 1995 · ‎ScienceContreras , P. D - Serine antagonized phencyclidine and MK - 801 . Hudzik , T. J. and Slifer , B. L. Interaction of sigma and PCP - like drugs on operant .(+)-MK 801 Maleate | Potent NMDA antagonist. (+)-MK 801 말레에이트(MK-801 말레에이트)는 쥐의 뇌막에서 Kd가 37.2nM인 강력하고 선택적이며 비경쟁적인 NMDA 수용체 길항제입니다. Rating: 5 · ‎1 review · ‎$35.00 to $140.00 · ‎In stockАвтомобили — Berkat — Страница №4. Транспорт › Автомобили› ВАЗ ID: 4682718 Цена: 270 000 руб Салаудин Телефон: +7(988)801-25-06 Экажево Комментарии: 3 Просмотры: 167 Дата: Вчера 12:26 .Dizocilpine (MK-801) | NMDA Receptor Antagonist. Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes.